Department of Biochemistry and Molecular Biology
Indiana University School of Medicine
- B.S. Biology/Philosophy, 1999. East Tennessee State University, Johnson City, TN.
- Ph.D. Biochemistry, 2004. The University of Kentucky, Lexington, KY.
- Assistant Professor, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana
- Member, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana
- Associate Member, Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana
Proper regulation of RNA Polymerase II (RNAPII) transcription is required to control gene expression. Gene expression is often altered in human diseases such as cancer, neurological disorders, and viral infection. In order to combat RNAPII associated defects during the course of disease progression, the basic mechanisms that dictate RNAPII activity must be understood. Specifically, our research will focus on RNAPII elongation and termination during the production and processing of messenger RNA. We study the role of numerous proteins that interact with RNAPII during mRNA production using quantitative proteomics approaches. In addition to the pursuit of hypothesis driven research problems, we also work to develop new computational methods for proteomics. Using these approaches we focus on the quantitation of protein-protein interaction dynamics, protein stoichiometry within a protein complex, and identification and quantitation of post-translational modifications such as phosphorylation, acetylation, and methylation.