The main research I am interested in is to develop statistical methodologies for finding susceptibility genes of human complex disease traits such as asthma, hypertension and otitis media. Generally my research involves (1) implementing new statistical models for quantitative trait loci (QTL) using the combined information of linkage and linkage disequilibrium (LD); (2) establishing association studies for QTL mapping in various cases such as multivariate traits, longitudinal traits; (3) developing statistical frameworks for genome-wide based genetic linkage and association study; (4) evaluating statistical properties of allele sharing statistics in non-parametric linkage analysis;(5) collaborative studies that have scientific questions in gene mapping.