| About Us - Lang Li Lab |
Welcome
to the laboratory of Lang Li in the Center for Computational Biology and
Bioinformatics (CCBB). The laboratory research focuses are
translational biomedical informatics, pharmacometrics, pharmacogenetics,
and system biology.
My
translational biomedical informatics
research focuses on drug-drug interaction (DDI) based literature
discovery, electronic medical record based DDI validation, in vitro
based DDI validation, and clinical trial based DDI validation. It is
applied to both drug safety and drug repositioning research.
My
pharmacometrics research focuses
include: identify new drug interactions and their clinical implications;
discover novel genetic and epigenetic factors in predicting drug
metabolism and transportation, and develop physiologically based
modeling system for drug exposure and drug effect prediction from
either clinical trials or clinical practice. We use statistics,
bioinformatics, mathematics, literature mining, and biology experiments
to develop and validate our modeling system.
My
pharmacogenetics and pharmacogenomics
research focus on either candidate gene or genome-wide association
studies for the drug response. Scientifically, we are interested in both
cancer and cardiology related pharmacogenetics studies.
Computationally, we are developing algorithms for clinical trial
design and predictive signatures.
My
system biology research focus
is to identify static and dynamic networks for cancer molecular
mechanisms, especially the estrogen signaling pathway. We are developing
multiple modeling systems from the data consists of SNPs, gene
expression, DNA methylation, histone modifications, transcription
factors, and microRNA.
